22 lines
1.1 KiB
Text
22 lines
1.1 KiB
Text
mRNA WTS FOR EUKARYOTES SARGAN,GREGORY,BUTTERWORTH FEBS LET 147 133-136 1982
|
|
P -7 -6 -5 -4 -3 -2 -1 1 2 3
|
|
102102102102102102102102102102
|
|
T 19 24 31 12 0 18 5 0102 0
|
|
C 20 15 32 65 5 42 52 0 0 0
|
|
A 50 27 27 19 86 36 34102 0 0
|
|
G 6 29 12 6 11 6 11 0 0102
|
|
VIRAL ONLY
|
|
P -7 -6 -5 -4 -3 -2 -1 1 2 3
|
|
41 41 41 41 41 41 41 41 41 41
|
|
T 14 12 16 4 2 13 9 0 41 0
|
|
C 7 3 13 17 7 9 14 0 0 0
|
|
A 15 10 6 10 27 15 9 41 0 0
|
|
G 5 16 6 10 5 4 9 0 0 41
|
|
This paper puts forward the hypothesis that there is an interaction between
|
|
some mRNA leader sequences and a highly conserved structure in the 18S rRNA
|
|
of eukaryotic ribosomes. The attempt to substantiate the hypothesis includes
|
|
a table of base frequencies for sequences immediately 5' to start codons.
|
|
They examined 102 sequences and I have used the base frequencies they found
|
|
as a weight matrix for searching for eukaryotic gene starts. I don't yet
|
|
know how good this method is. The viral sequences were found to be slightly
|
|
different but the separate table shown here is not used in the program.
|