23 lines
1.1 KiB
Text
23 lines
1.1 KiB
Text
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mRNA WTS FOR EUKARYOTES SARGAN,GREGORY,BUTTERWORTH FEBS LET 147 133-136 1982
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P -7 -6 -5 -4 -3 -2 -1 1 2 3
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102102102102102102102102102102
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T 19 24 31 12 0 18 5 0102 0
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C 20 15 32 65 5 42 52 0 0 0
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A 50 27 27 19 86 36 34102 0 0
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G 6 29 12 6 11 6 11 0 0102
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VIRAL ONLY
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P -7 -6 -5 -4 -3 -2 -1 1 2 3
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41 41 41 41 41 41 41 41 41 41
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T 14 12 16 4 2 13 9 0 41 0
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C 7 3 13 17 7 9 14 0 0 0
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A 15 10 6 10 27 15 9 41 0 0
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G 5 16 6 10 5 4 9 0 0 41
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This paper puts forward the hypothesis that there is an interaction between
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some mRNA leader sequences and a highly conserved structure in the 18S rRNA
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of eukaryotic ribosomes. The attempt to substantiate the hypothesis includes
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a table of base frequencies for sequences immediately 5' to start codons.
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They examined 102 sequences and I have used the base frequencies they found
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as a weight matrix for searching for eukaryotic gene starts. I don't yet
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know how good this method is. The viral sequences were found to be slightly
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different but the separate table shown here is not used in the program.
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